Anders began showing interest in music as a child, he did his first stage-performance at age of 7. Anders first studied music at Koblenz Eichendorff-Gymnasium. After having performed at several clubs and discothèques, in 1979, he participated in a music contest organized by the radio station Radio Luxembourg which he walked away from without earning enough points. Two days after the contest, Anders was offered a record contract by the same jury members of the radio contest. It was then that his career officially began when in 1980, at age of 17, he released his debut single "Judy". Anders released several other singles produced by Daniel David including "Du weinst um ihn", which he performed on Michael Schanze's TV show Hätten sie heut' zeit für uns. In 1983, he met Dieter Bohlen who produced "Was macht das schon", the German cover version of F. R. David's "Pick Up the Phone" and also "Heißkalter Engel", the German cover version of Real Life's "Send Me an Angel". From late 1983 to the mid of 1984 Bohlen produced other tracks for Anders including "Wovon träumst du denn", "Endstation Sehnsucht" and "Es geht mir gut heut' Nacht". The success, however, came when in late 1984, Anders and Bohlen formed the successful duo Modern Talking, which they started things off by a worldwide hit single "You're My Heart, You're My Soul".
In late 1987, Anders and Bohlen decided to terminate Modern Talking and go their separate ways due to constant quarrel between the two. Shortly after which Anders went on a long tour performing before as many as 85,000 fans, the tour involved cities like Cape Town, Johannesburg, Hong Kong, Singapore, Taipei, Viña del Mar and Moscow. This drove Anders to leave Germany for the United States, where in 1989, Anders released his first solo album Different with more pop style rather than dance, which he produced together with Elton John's producer Gus Dudgeon and a-ha's producer Alan Tarney. The first single "Love of My Own" released in the same year is considered the biggest success of his solo career at that time. The second albumWhispers was released in 1991, three singles were released off Anders' second solo album "The Sweet Hello, The Sad Goodbye" written by Roxette member Per Gessle, "I Can't Give You Anything (But My Love)" and "True Love". In 1992, Anders released his third album Down on Sunset, the singles "How Deep Is Your Love" and "Standing Alone" (Duet with Glenn Medeiros) found some success both in Germany and Austria. Anders released his fourth solo album When Will I See You Again in 1993. The first single "When Will I See You Again" featured the original singers of the song, The Three Degrees. Also, in 1993, Anders experienced something new as he got a part in a Swedish movie Stockholm Marathon. He also wrote the title-song for that film "Marathon of Life", which is one of the tracks in his 1993's album When Will I See You Again. In 1994, he came back with an album Barcos de Cristal, which he released in Spanish only, this album contained songs from albums of 1992 and 1993, all redone in Spanish. Anders released one more album in 1995 called Souled, which he produced together with Peter Wolf, this album contained a duet featuring The Pointer Sisters "Feel for the Physical". Things for him then were quiet until March 1998 when Thomas Anders and Dieter Bohlen announced the reunion of Modern Talking. The duo split again in 2003 eventually selling over 65 million albums worldwide between 1998 and 2003.
In late 2003 Anders signed a contract with BMG international as a solo artist after their final album of Modern Talking. The first single "Independent Girl" released in November 2003 reached #17 in the German single chart, and his album This Time released in 2004 entered the Top 20 as well. The second single "King of Love" reached the Top 20 in Spain and the Top 40 in Germany. At this point, Anders was working with his new producer Peter Ries, who previously had worked with such artists as Sandra andNo Angels. Thomas Anders received an offer from NDR to host the Eurovision Song Contest 2004, 11 million viewers who already knew Anders as a singer watched him as a TV personality. Also, in 2004, Anders was asked to record the ballad "Just Dream" which was to be the official anthem for the ballet Holiday on Ice (which later was entered in Guinness Record Book). The song can be heard during the international three-year Holiday on Ice tour. A year after, Anders won his legal battle against Dieter Bohlen, which was due to wrongful allegations by Bohlen, written in his autobiographical book. In March 2006, Anders got involved in Eurovision Song Contest again; however, he was one of the contestants to represent Germany in the Eurovision Song Contest 2006 alongside with the Greek-born Vicky Leandros (Eurovision Song Contest 1972 winner) and country band Texas Lightning featuring comedian Olli Dittrich. However, the spectators chose the latter. Also in the same year, Anders left BMG and joined Edel Records and released his swing-album Songs Forever. In April 2006, his The DVD-Collection arrived in stores, which contained 20 videos of his solo career as well as some hits taken from Modern Talking period. In July 2008, two download singles were released "Ibiza Baba Baya" and "For You". Anders announced the German Eurovision results in 2009. His 2010 album Strong reached the platinum status in Russia. The first single "Why Do You Cry" from his latest material peaked at No. 21 on Russian Airplay Chart.
In 2011, Anders came back collaborating with Uwe Fahrenkrog, German musician and songwriter. The duo's first single together called "Gigolo" was released on May 27, 2011 in Germany which, so far, has peaked at No.40 there.Their album Two was released on June 10, 2011. The single "Gigolo" is written and produced by Uwe Fahrenkrog-Petersen Thomas Troelsen. The duo appears under the name Anders | Fahrenkrog.